Osteoporosis And Bone Disease

Osteoporosis causes bones to become weak & brittle due to low bone mass & bone tissue deterioration.
Chronic & progressive
Most common origin of bone disease in U.S.
Fractures transpire easily.
Primary cause of fractures in elderly.
Bone formation should match bone resorption.
Osteoblasts
Build (form) new bone & generate organic matrix & mineralize bone.
Osteoclasts
Breaks down bone & cause bone resorption.
Osteocytes
Maintain bone by directing when/where bone remodeling is to occur.
Parathyroid Hormone (PTH), will stimulate bone formation while estrogen preserves the bones density.
Bone remodeling occurs throughout our lifespan.
Bone formation (osteoblasts) follows bone resorption (osteoclasts).
A main cause of Osteoporosis is an imbalance where bone resorption exceeds bone formation.
Causes of Osteoporosis include:
Aging: Naturally decreases supply of osteoblasts.
Bone resorption surpasses bone formation. (After 30-40 years of age).
Estrogen Deficiency: Fast-tracks (accelerates) bone loss.
Causes increased levels of bone resorption & decreased levels of bone formation.
Low estrogen levels causes T-cells to increase number of osteoclasts.
Decreased gonadal hormones: Increases number of osteoclast progenitor