physio
DE LA SALLE - HEALTH SCIENCES INSTITUTE
COLLEGE OF MEDICINE
DEPARTMENT OF PHYSIOLOGY
EXPERIMENT ACTIVITY - 1,2,3,4
Group 8 - A
ABUYUAN, Ian Joshua R.
COMIA, Philip Edward
DE LUNA, Alvin Michael M.
DUGUIL, Darryl Young S.
FUENTES, Anne Nicole S.
MANGAHIS, Arjane Danielle O.
SISON, Renee Ann S.
TAN, Adam L.
July 31, 2013
EXPERIMENT NO. I
BLOOD TYPING AND CROSSMATCHING
A. BLOOD TYPING
DISCUSSION:
1. Explain why there are different blood groups and how does the principle of blood typing work. Why is this important to know?
Existence of different blood groups is the result of the presence of different antigens and antibodies in blood. Blood typing is performed by mixing blood with agglutinins/antibodies. If a sample of blood agglutinates with a serum containing anti-A antibodies, the blood contains A antigens. If a sample of blood agglutinates with a serum containing anti-B antibodies, the blood type contains B antigens. If the blood agglutinates with both serums, it is AB. When no agglutination occurs with either serum, it is blood type O. Health care providers need to know one 's blood type when one will receive a blood transfusion or transplant because not all blood types are compatible with each other. Administration of the incompatible blood products would lead to immediate destruction of infused blood or even acute medical illness to the patient, hence, it is vital that the correct blood type of the donor and the recipient is determined and their blood were properly matched.
2. Which blood type is known as the universal donor? Explain why.
Type O individual are "universal donors" because they lack A and B antigens and type O blood can be given to anyone without producing a transfusion reaction due to ABO incompatibility. This blood type does not have any antigen, which will bind to the antibodies present in blood type A and B, therefore no reaction/agglutination will occur to
COLLEGE OF MEDICINE
DEPARTMENT OF PHYSIOLOGY
EXPERIMENT ACTIVITY - 1,2,3,4
Group 8 - A
ABUYUAN, Ian Joshua R.
COMIA, Philip Edward
DE LUNA, Alvin Michael M.
DUGUIL, Darryl Young S.
FUENTES, Anne Nicole S.
MANGAHIS, Arjane Danielle O.
SISON, Renee Ann S.
TAN, Adam L.
July 31, 2013
EXPERIMENT NO. I
BLOOD TYPING AND CROSSMATCHING
A. BLOOD TYPING
DISCUSSION:
1. Explain why there are different blood groups and how does the principle of blood typing work. Why is this important to know?
Existence of different blood groups is the result of the presence of different antigens and antibodies in blood. Blood typing is performed by mixing blood with agglutinins/antibodies. If a sample of blood agglutinates with a serum containing anti-A antibodies, the blood contains A antigens. If a sample of blood agglutinates with a serum containing anti-B antibodies, the blood type contains B antigens. If the blood agglutinates with both serums, it is AB. When no agglutination occurs with either serum, it is blood type O. Health care providers need to know one 's blood type when one will receive a blood transfusion or transplant because not all blood types are compatible with each other. Administration of the incompatible blood products would lead to immediate destruction of infused blood or even acute medical illness to the patient, hence, it is vital that the correct blood type of the donor and the recipient is determined and their blood were properly matched.
2. Which blood type is known as the universal donor? Explain why.
Type O individual are "universal donors" because they lack A and B antigens and type O blood can be given to anyone without producing a transfusion reaction due to ABO incompatibility. This blood type does not have any antigen, which will bind to the antibodies present in blood type A and B, therefore no reaction/agglutination will occur to
References: Guyton and Hall Textbook of Medical Physiology Twelfth Edition Ganong 's Review of Medical Physiology 23rd Edition National Medical Services for Independent Study: Physiology 3rd Edition World wide web (mostly google) www.wikipedia.com American Association of Blood Banks. 8101 Glenbrook Road, Bethesda, MD 20814. (301) 907-6977. http://www.aabb.org. http://www.livestrong.com/article/136305-what-are-dangers-blood-transfusion/#ixzz2aXJZ2BGB§