To the Fellowship Selection Committee:
I am writing in support of Janet Lerner’s application for an NSF Fellowship. Janet is genuinely a gifted student with great potential as a research scientist. I encourage you to give her your most careful consideration.
Janet has been conducting an independent honor’s research project in my laboratory for the past year. Without a doubt, Janet is one of those rare individuals that comes along only once every few years; she is highly intelligent (her transcript is blemished by a single “B”), inquisitive, motivated, and creative. Janet has just the right combination of assertiveness and respect to make her a joy to work with in the lab. She takes directions very well, but she is not timid about questioning experimental details or rationale. This is a student that I will enjoy watching develop into a highly productive research scientist.
For her honor’s thesis I have given Janet a demanding project that I would normally reserve for my graduate students. Even before entering my lab, she had read a large number of articles that described recent advances with the virus that we study in the lab—JC virus (JCV). Expecting that I would need to explain many of the techniques used in these studies and to discuss the rationale behind the experiments, I was surprised to discover that she already had a firm grasp of these concepts and was ready to discuss the science on a much higher level. Together we decided that her project would entail a mutational analysis of a specific functional domain of the major regulatory protein of JCV, the multifunctional T protein.
To emphasize the scope and importance of Janet’s work, a summary of the relevant science follows.
JCV is an important opportunistic pathogen; it has infected >70% of the world’s population and it remains latent in the kidneys and brains of most of us. In severely immunocompromised individuals,
JCV may cause the fatal demyelinating brain disease