Similarities Between Cyclophosphamide And Vinblastine

Cyclophosphamide and Vinblastine are anticancer drugs used to treat a variety of cancers. Cyclophosphamide is synthetically produced and used to treat Hodgkin's disease, non-Hodgkin's lymphomas and neuroblastoma. It is also often used in conjunction with other anticancer drugs. (http://medical-dictionary.thefreedictionary.com/Anticancer+Drugs) (http://cyclophosphamide.net/)
A drug which may be used in conjunction with Cyclophosphamide is Vinblastine, commonly known as Cytoxan or Neosa. Like Cyclophosphamide, Vinblastine is also used to treat Hodgekin’s disease and non-Hodgekin’s lymphoma, however it is also used to treat a variety of other cancers such as testicular, breast, lung, and bladder cancer. It is also used in the treatment of certain
COMPOUND?).(https://en.wikipedia.org/wiki/Cyclophosphamide) Vinblastine is vinca alkaloid with the chemical formula C46H58N4O9. (http://www.drugbank.ca/drugs/DB00570)
(ADD MORE BIOMECHANICAL PROPERTIES OF VINBLASTINE). Although Cyclophosphamide is synthetically produced, Vinblastine is primarily derived from the Madagascar Periwinkle flower, or Catharanthus Roseus. However, the extraction is expensive and yields of Vinblastine are low at an overall yield of about 10%. This has led to a recent surge in the study of how to synthesize the drug, and currently the yield of the synthesized version is at around 22%, which makes it much more viable. However, this process is still developing.
The microtubules of a cell are important in maintaining the structure of a cell and make up part of the cytoskeleton by forming the mitotic spindle. They are also important in the structure of cilia and flagella. (https://en.wikipedia.org/wiki/Microtubule). Vinblastine has different effects depending on the concentration of the dosage. When used in low concentrations, it suppress microtubule dynamics whilst at higher doses they reduce microtubule polymer mass. In both situations, cell is prevented from entering anaphase. (https://en.wikipedia.org/wiki/Vinblastine#Mechanism_of_action). As a result, the cancer cells are unable to multiply successfully. (http://www.netdoctor.co.uk/cancer/medicines/velbe.html)

However due to unspecificity of target cell, both damage non cancerous cells as well.

How taken:
Cyclophosphamide is able to be taken in a number of ways. Primarily it is given by injection directly into a vein or by an intravenous infusion. It can also be taken in tablet form or by a shot into a muscle, abdominal lining or the lining of the lung. The method used depends on the diagnosis of the cancer. (http://chemocare.com/chemotherapy/drug-info/cyclophosphamide.aspx)

Unlike cyclophosphamide, vinblastine can only be given through an intravenous injection or infusion. If it were to escape the vein or be administered in any other fashion,