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Spinal Cord Injury Research Paper

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Spinal Cord Injury Research Paper
Neurosci Bull June, 2013. http://www.neurosci.cn
DOI: 10.1007/s12264-­013-­1359-­2

1

·Review·

Combination treatment with chondroitinase ABC in spinal cord injury—breaking the barrier
Rong-­Rong Zhao, James W Fawcett
Brain Repair Centre, University of Cambridge, UK
Corresponding author: James W Fawcett. E-­mail: jf108@cam.ac.uk
© Shanghai Institutes for Biological Sciences, CAS and Springer-­Verlag Berlin Heidelberg 2013

After spinal cord injury (SCI), re-­establishing functional circuitry in the damaged central nervous system (CNS) and the inhibitory environment in the damaged CNS. Several treatment strategies have been developed …show more content…
B: Several strategies improve spinal cord repair, including chondroitinase ABC (ChABC) treatment to degrade CSPGs in the glial scar, cell implantation to reconnect the circuitry or provide a tissue bridge for axons to grow through (green spheres), ion channel expression to re-­establish neuronal activity to that of the juvenile state (blue dots), and anti-­Nogo treatment to block myelin inhibitors. Combinations of these strategies increase axon regeneration and plasticity, re-­connection of the circuitry (functional synapses represented by red dots), and improve cell implant survival and integration into host tissue.

integration of cells implanted into the surrounding tissue by

disorganized smooth muscle fibers and collagen deposit

removing the CSPG barrier. This was followed by an in vivo

were found in comparison to the control …show more content…
Analysis of the causes and types of traumatic spinal cord

6

Neurosci Bull June, 2013

injury based on 561 cases in China from 2001 to 2010.
Spinal Cord 2013, 51: 218–221.

465–466.
[16] Wang D, Ichiyama RM, Zhao R, Andrews MR, Fawcett

Lin R, Kwok JC, Crespo D, Fawcett JW. Chondroitinase

JW. Chondroitinase combined with rehabilitation promotes

ABC has a long-­lasting effect on chondroitin sulphate

[2]

recovery of forelimb function in rats with chronic spinal cord

glycosaminoglycan content in the injured rat brain. J
Neurochem 2008, 104: 400–408.

injury. J Neurosci 2011, 31: 9332–9344.
[17] Zuo J, Neubauer D, Dyess K, Ferguson TA, Muir D.

Gilbert RJ, McKeon RJ, Darr A, Calabro A, Hascall VC,

Degradation of chondroitin sulfate proteoglycan enhances

Bellamkonda RV. CS-­4,6 is differentially upregulated in
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