Summary Of Curcuma Longa

Curcumin is found in the rhizome of Curcuma longa. It exhibits various biological activities like anti-cancer, anti-inflammatory, anti-viral, anti-bacterial, anti-oxidant and nematocidal activities. Due to its poor solubility there is a need to formulate this curcumin for better bioavailability. Curcumin was extracted by acetone using soxhlet apparatus and evaporated by means of vacuum rotary evaporator. The presence of curcumin was confirmed by differential scanning calorimetry. Nanosuspension was prepared by bottom up method using acetone and water solvent system. Stabilizers were added under optimized conditions in order to achieve suitable quality of nanosuspension. Then it was analyzed using particle size and zeta potential analyzers for
Curcumin derived from turmeric (Curcumin longa) is being used form thousands of years as a healing agent for variety of illnesses [3]. Research over the last few decades has indicated that curcumin is a potent anti-inflammatory agent with strong therapeutic potential against a variety of cancers [4]. A large number of in vitro and in vivo studies in both animals and man have indicated these activities. Safety evaluation studies indicate that curcumin is well tolerated at a very high dose without any toxic effects [5]. Most drugs currently available for the treatment of cancer have many constrain due to poor solubility and associated diminished bioavailability that leads to overdose toxicity apart from inefficient therapeutic action. In economic point of view, higher doses cost more expenses in the procurement for the beneficiary. As these drugs are obtained from natural resources, meeting out constant supply against the demand become difficult. Poor yield on purification is another issue that depends on expression of secondary metabolites by plants and physical stability of compounds[6] . Hence, global community seeks a drug with either high potency or efficient formulation for