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The in-Vitro Acetylcholine Antagonism Study of Tomato (Solanum Lycopersicum) Compared to Lagundi (Vitex Negundo L) Using Rat Duodenum

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The in-Vitro Acetylcholine Antagonism Study of Tomato (Solanum Lycopersicum) Compared to Lagundi (Vitex Negundo L) Using Rat Duodenum
Chapter I

Background of the Study:
Bronchial asthma is a chronic relapsing inflammatory disorder with increased responsiveness of tracheobronchial tree to various stimuli, resulting in paroxysmal contraction of bronchial airways.
It refers to a condition of subjects with widespread narrowing of the bronchial airways which changes in severity over short periods of time, either spontaneously or under treatment, and is not due to cardiovascular disease
According to the CDC, more than 22 million Americans, including 6.5 million children under 18, suffer with asthma today. Allergy clearly plays an important role in many asthma cases but not in all. Although drug-induced bronchospasm occurs most commonly in patients with known asthma, the agents themselves may produce asthma. The best-known of these is aspirin, but several other anti-inflammatory agents have been implicated.
4
Tomatoes are commonly used for cooking. They are rich in lycopene and glutamate which is why they are both healthy and delicious. Although tomatoes are perceived as vegetables, fact is, they are fruits. They are made in different forms such as tomato sauce, tomato juice, tomato soup, sun-dried tomatoes, canned tomatoes and many more. They contain such health benefits, one of which is its ability to treat asthma. So many people suffer from this kind of sickness, and sometimes, it causes an individual’s death. The medication for asthma is expensive, thus we, the researchers, decided to investigate whether the tomato juice extract can be used as a substitute anti-asthma medicine.

Statement of the Problem: Basically, the problem of the researchers in this study is to determine whether there is any scientific basis for the folkloric claim that Solanum lycopersicum (Plum Tomato) possesses anti-asthma (bronchodilating) property comparable to the herbal standard bronchodilator, which is Vitex negundo (Lagundi aqueous) extract. 5 Objectives: Specifically, it sought to: 1. Compare the



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