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Zidovudine Case Study

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Zidovudine Case Study
Objective: In the present study, an attempt was made to improve the bioavailability of Zidovudine by formulating into Orodispersible tablets, as it has poor bioavailability and extensive pre systemic metabolism.
Methods: In the present study, the mucilage extracted from Fenugreek seeds (Trigonella foenum-graecum) was used as superdisintegrant. The oral dispersible tablets were prepared by using wet granulation technique. A three factor two level (23) central composite design was employed for the optimization of formulation. The input variables chosen are amount of fenugreek mucilage, amount of mannitol, and concentration of PVP and the response parameters chosen for the optimization were Dissolution efficiency at 10 min and In-vitro dispersion
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The prepared formulations were evaluated for different pre-compression and post-compression parameters. The In-vitro dissolution studies were carried out as per USP. The drug release profiles show that all the four optimized formulations show 100% drug release in about 20- 30 min. The actual responses such as dissolution efficiency and In-vitro dispersion time are closer to the predicted responses by design.
Conclusion: It can be concluded that the fenugreek mucilage used in the study as superdisintegrant was a good choice in making orodispersible tablets of Zidovudine and the adopted Central composite design was successful in optimizing the formulations as actual responses were comparable to that of predicted responses by design.
Key words: Zidovudine, Fenugreek mucilage, Superdisintegrant, Central composite design, Orodispersible
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Loss on drying
1g of the sample was transferred into each of several Petri dishes and then dried in an oven at 105oC until a constant weight was obtained. The moisture content was then determined as the ratio of the weight of moisture loss to weight of sample expressed as a percentage. pH determination The pH of each of 1% suspension was measured using a pH meter to check any hydrolysis or microbial decomposition of suspensions. The change in pH is attributed to hydrolysis or microbial decomposition.
Flow properties
The flow properties of the fenugreek mucilage were studied by determining Angle of repose, carr’s compressibility index and hausner

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