has more concentration of K+. The membrane is permeable to a particular ion‚ that ion will diffuse down its concentration gradient from a region of higher concentration to a region of lower concentration. 2. Explain why increasing extracellular K+ causes the membrane potential to change to a less negative value. How well did the results compare with your prediction? Your answer: Because outside has more K+‚ the rate of diffusion is less. The resting membrane potential will become less negative
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ANTI-INFECTIVES Anti-infective agents are drugs that are designed to act selectively on foreign organisms that have invaded and infected the body of a human host. Ideally‚ these drugs would be toxic to the infecting organisms only and would have no effect on the host (or human) cells. OVERVIEW • Antimicrobial therapy (often termed “antibiotic therapy”) is the use of medications to treat infections caused by bacteria‚ viruses‚ and fungi. • Antimicrobial must use selective toxicity to kill
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Resting Membrane Potentials Dr Penny Murphy Objectives The student should be able to: Describe the basic building blocks of the central nervous system. Explain what a “resting membrane potential” (RMP) is and how it is generated. Include the characteristics of the phospholipid bilayer‚ leak membrane channels and the diffusion of K+ ions‚ and the role of the Na+/K+ ATPase pump. Explain how and why increasing the permeability of the membrane to Na+ ions will affect the membrane potential
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few decades‚ membrane technology has been a great attention for gas separation technology especially for natural gas sweetening. The intrinsic character of membranes makes them fit for process escalation‚ and this versatility could be the significant factor to induce membrane technology in most gas separation areas. Membranes were synthesized with various materials which depended on the applications. The fabrication of polymeric membrane was one of the fastest growing fields of membrane technology
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and defects in membrane permeability. Cells are unable to properly function if they lack certain important cell factors. ATP depletion A cell needs mitochondrial adenosine triphosphate in order to function properly which is why when a cell is injured or dying‚ a common theme seen is lost or decreased ATP. ATP loss or a deduction in ATP synthetization is likely to cause many other problems such as swelling of the cell‚ a deduction in the making of proteins‚ error in normal membrane transporting. These
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of proteins such as membrane receptors or ion channels. Ischemia will cause the dissociation of the cytoskeleton due to increase the intracellular concentrations of Ca+2 during ischemia which activate multiple phosphorylases and proteases that dissociate the cytoskeleton‚ thereby eliminating the functions that depend on its integrity‚ such as phagocytosis‚ exocytosis‚ myofilament contraction and intercellular communication(Gourdin et al.‚2013).
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Cell injury In this topic we are going to cover Cell injury Causes of cell injury Mechanism of cell injury Morphologic alterations in cell injury Morphologic types of necrosis Objectives Describe cell injury List the causes of cell injury Discuss how depletion of ATP causes cell injury Describe how mitochondrial damage cause cell injury Explain the mechanism of cell injury by free radicals Discuss how calcium ion influx cause cell injury Cell injury cell injury results when cells
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“MEMPOT”© – Computer Simulation of Membrane Potential Measurements INTRODUCTION “MEMPOT”© is an interactive graphical simulation program that is designed to show how cell membrane potentials are measured with microelectrodes in the laboratory situation. The simulation shows how the membrane potential depends on the external potassium‚ [K+]o and external sodium‚ [Na+]o concentrations and the relative permeability of the membrane to these ions. The program simulates membrane potential measurements in any
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why increasing extracellular K+ causes the membrane potential to change to a less negative value. How well did the results compare with your prediction? Your answer: If extracellular K+ is increased then the intracellular K+ will decrease. Fewer intracellular K+ ions would result in the membrane potential being less negative. This is what I predicted to happen. 3. Explain why a change in extracellular Na+ did not significantly alter the membrane potential in the resting neuron? Your answer:
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dendrite -> soma -> axon -> synapse Lecture 2 – Chapters 4 & 5 Ion channels and signalling - ions are separated by cell membrane; when ion channels are opened‚ ions flow -> generating electrical signals -> so neurons can communicate info through these electrical signals - neurons generate a constant negative voltage across membrane: the rmp - an AP abolishes the –ve rmp‚ making membrane potential transiently positive - we can record and measure ion currents using electrophysiology - hyperpolarization
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