of Acetanilide Abstract Recrystallization is a common method of purifying organic substances through the difference in solubility at different temperature. In this experiment‚ acetanilide was produced by acetylation of aniline with acetic anhydride. The crude acetanilide was dissolved in a solvent in a heating water bath. The solution was cooled slowly in an ice bath as crystals form out. As the compound crystallizes from the solution‚ molecules of other compounds dissolved in solution are
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cold water‚ and it is isolated by filtering the chilled reaction solution. Purification is essential to remove any unreacted salicylic acid and acetic anhydride as well as the acetic acid product and phosphoric acid. Acetic anhydride is caused to decompose by the addition of water once the formation of aspirin is complete. C4H6O3 (Acetic anhydride) + H2O (Water) -------------------------> 2C2H4O2 (Acetic Acid) The acetic acid and phosphoric acid are water soluble and it is removed by
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Acetylsalicylic acid is the active pharmaceutical ingredient in aspirin and can be synthesized by the esterification reaction of salicylic acid and acetic anhydride in the presence of an acid catalyst. An esterification reaction is when an acid is converted into an ester by combining with an alcohol and removing a water molecule. When heating the salicylic acid mixture in the warm water bath‚ the mixture should be removed from the bath within 8 minutes‚ to reduce the chance of the acetylsalicylic
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following From the balanced reaction above‚ it can be seen that the stoichiometry between salicylic acid and acetic anhydride is 1: 1. In this experiment‚ 21.7mmol of salicylic acid was used to react 6.0mL of acetic anhydride and salicylic acid was limiting reagent. The expected amount of salicylic acid used: 21.7/1000*138.12=2.99g=3.0g The expected amount of acetic anhydride: 21.7/1000*102.09=2.215g=2.2g Reactants | Formula/MWt | Min. Mole Ratio | Expected amount used | Expected vol./density
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is a combination of the mixture. The addition of a fractionating column allows numerous small distillations to occur within the column as the vapour rises towards the condenser. This experiment will demonstrate the separate a 50:50 mixture of toluene and cyclohexane by two methods and will require two separate equipment setups - one with the fractionating column (fractional distillation) and condenser and one with only the condenser (simple distillation). The results will show the contrast between
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halogenation reaction. If the bromine reacted with the alkene the bromine would discolor from orange and turn clear. Experiment Part A) Solubility of Alkanes: 1 mL of nine solvents (water‚ methanol‚ n-butanol‚ ethylene‚ glycol‚ acetone‚ hexane‚ toluene‚ ethyl acetate‚ and dichloromethane.) was added to nine sample vials. Each vial then had 0.5 mL of the alkane decalin added to each one. The mixtures were stirred to determine if the materials dissolved. If the material was insoluble it was heated
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this experiment you will prepare two esters of o-hydroxybenzoic acid‚ more commonly known as salicylic acid. One of the esters‚ acetylsalicylic acid‚ is aspirin‚ the common analgesic. We will synthesize aspirin by mixing salicylic acid with acetic anhydride. The second ester product is oil of wintergreen‚ or methyl salicylate‚ which we prepare by allowing salicylic acid to react with methyl alcohol. This compound‚ which has a familiar odor is used as
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purity of the synthesized sample by observing the melting point temperature range. The procedure performed in our experiment involved chemically reacting salicylic acid and acetic anhydride in order to form acetyl salicylic acid. The limiting reactant in this chemical reaction was salicylic acid‚ with acetic anhydride present in excess in order to react with any water produced during the reaction of the reactants‚ and thus improve the yield of aspirin. The addition of a catalyst‚ 85% phosphoric acid
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CHOONG SHING YI CHOONG SHING YI Preparation and Recrystallization of Aspirin Preparation and Recrystallization of Aspirin Date of the experiment: 9 May 2013 Date of submission: 23 May 2012 Date of the experiment: 9 May 2013 Date of submission: 23 May 2012 Synopsis 1. General Objective: To familiarize with the preparation of some simple organic compound and purify the compound by recrystallization. Specific Objective: The experiment is carried
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M. Drapesa‚ Arianne Valerie B. Escritor‚ Elisha Ellis R. Esteva Group 4 2B Medical Technology Organic Chemistry Laboratory ABSTRACT In this experiment‚ acetanilide was used as the pure organic compound. Acetylation of aniline and acetic anhydride yields the crude product or crude acetanilide. The crude acetanilide was purified by dissolving it in hot water and then the solution was cooled slowly by placing in an ice bath. The yielded crystals were pure acetanilide since molecules of other
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