IB1 Chemistry Practical #8 ANALYSIS OF ASPIRIN TABLETS For a long time the bark of the willow tree (salix alba) was used as a traditional medicine to relieve the fever symptoms of malaria. In the 1860’s chemists showed that the active ingredient in willow bark is salicylic acid (2-hydroxybenzoic acid) and by 1870 salicylic acid was in wide use as a pain killer (analgesic) and fever depressant (antipyretic). However‚ because it is a relatively strong acid‚ salicylic acid has the undesirable side effect
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Aspirin Aspirin is a salicylate‚ also known as a non steroidal anti-inflammatory drug (NSAID). It is the generic name of acetylsalicylic acid and is used clinically to treat fever‚ pain and inflammation as it works by preventing the formation of prostaglandin. Prostaglandin is the active agent that is responsible for the sensitisation at the nerve endings. It can be administered orally‚ rectally or by intravenous route. (6) Benzene ring Carboxylic acid Ester Alkane Aspirin has a pKa of 3.49
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Synthesis of Aspirin and Tylenol Kyla Wykoff Abstract Aspirin and Tylenol were synthesized by means of crystallization‚ recrystallization‚ and melting point determination. Synthesis produced significantly high percent yields for aspirin‚ however‚ produced extremely low and impure percent yields for Tylenol. A second group was also used to compare results and errors‚ in which they too were also producing extremely low percent yields of Tylenol. Therefore‚ error was based on the specific protocol
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Today‚ aspirin is one of the most widely used medication on this Earth and has been since its popular breakout in the late 1890s. Long before we were born there was no such thing of a medication called aspirin. Instead‚ ancient people used willow leaves and bark from trees to help relieve oneself from pain and fevers. Aspirin as we come to know it in the form of an acetylsalicylic acid‚ was introduced to the world by Chemist Felix Hoffmann who was working at Bayer pharmaceutical company located in
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crystallization indicates that the solution has become statured. This means that at each temperature recorded the solution contains the maximum quantity of solute that can be dissolved in that amount of solvent. Standard solubility table of Ammonium chloride Solubility g/100gH2O Temperature /°c/±0.1 60‚3 71‚3 55‚5 59‚3 51.3 52‚4 47‚7 47‚2 43‚4 41‚8 Uncertainties and errors of volume and temperature VOLUME H2O/ml/±0.05 Percentage uncertainty/% Temperature/°c/±0.1 Percentage
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SYNTHESIS OF THE PHARMACEUTICAL ASPIRIN (ACETYLSALICYLIC ACID) AIM: The aim for this experiment was to synthesise a small amount of aspirin with salicylic acid as the starting product and sulphuric acid as the catalyst. The product obtained from this reaction will be impure and will need to be purified. This will be done by recrystallization. We will then record the products’ melting point and calculate the yield in order to determine the degree of purity of the aspirin sample. Diagrammatic scheme for
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Synthesis of Aspirin and Oil of Wintergreen Janelle Alyssa P. Prudente De La Salle University-Dasmariñas Dasmariñas City‚ Cavite‚ Philippines ABSTRACT In this experiment‚ acetylsalicylic acid commonly known as aspirin and methyl salicylate‚ commonly known as oil of wintergreen‚ was synthesized from salicylic acid. This study will show that it is possible to show two very different organic compounds from the same common starting material. For the synthesis of aspirin‚ salicylic acid
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● Cobalt(II) Chloride Hexahydrate CoCl2.6H2O‚ was weighed in a weighing boat. The Cobalt(II) Chloride Hexahydrate was transferred into a 100mL volumetric flask dissolved in water. ● 25 mL of the dissolved was measured‚ using a graduated cylinder and few of the dissolved Cobalt (II) Chloride Hexahydrate‚ was poured into test tube. The test tube was labeled with a tape‚ to signify 25 mL and the spectrophotometer was used to record the U-V visible ABS (absorbance spectrum) with the wavelength of 515
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October 17 & October 24‚ 2012 How is Aspirin Made? This lab is about synthesizing aspirin using a hotplate to heat the reaction. It involved vacuum filtration‚ recrystallization‚ and comparing the properties of aspirin with salicylic aspirin. The first thing we did in this lab was make a hot-water bath by putting a beaker with water on a hot plate. After measuring out 2.1 grams of salicylic acid and 3 ml of acetic anhydride‚ we mixed the two together‚ along with 3 drops of sulfuric acid. We
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Aspirin analysis Introduction Aspirin‚ which is also known as acetylsalicylic acid. C9H8O4 is the chemical format for Asprin. The chemical structure of aspirin: Aspirin is anti-inflammatory. Aspirin is prepared by chemical synthesis from salicylic acid‚ by acetylation with acetic anhydride. The fact that it is an acid allows us to quantify the amount of aspirin in a solution. We would do this by by using an acid-base titration. Sodium hydroxide (NaOH) will be used In this experiment as the
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