RECRYSTALLIZATION OF ACETANILIDE ABSTRACT Recrystallization is the primary method for purifying solid organic compounds through the differences in solubility at different temperatures. In this experiment‚ a suitable solvent was first determined. Acetanilide was produced by acetylation of aniline with acetic anhydride. The crude acetanilide was dissolved in a solvent in a heating water bath. The hot solution was filtered and the filtrate‚ cooled slowly in an ice bath as crystals started forming
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Organic Chemistry Laboratory ABSTRACT In this experiment‚ acetanilide was used as the pure organic compound. Acetylation of aniline and acetic anhydride yields the crude product or crude acetanilide. The crude acetanilide was purified by dissolving it in hot water and then the solution was cooled slowly by placing in an ice bath. The yielded crystals were pure acetanilide since molecules of other compounds present in the crude acetanilide were excluded from the growing crystal lattice. Lattice is
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RECRYSTALLIZATION OF ACETANILIDE De Ocampo‚ Yves Aaron Julian Q.‚ Dela Vega‚ Roderick B. Jr.‚ Elguira‚ Cedric Tristan D. Enriquez‚ Joanne B.‚ Gabat‚ John Elliot N. Group 5 2D-Medical Technology Faculty of Pharmacy‚ University of Santo Tomas ABSTRACT The experiment was executed in order to purify compounds through recrystallization. Recrystallization is the primary used operation for purifying solid organic compounds that differ in solubility at different temperature. It is a process of dissolving
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substitution at the 4-position over the 2-positions which it shields. Aniline is the simplest aromatic amine and is synthesised by first nitrating benzene using a concentrated mixture of nitric acid and sulphuric acid to give nitrobenzene which is then hydrogenated in the presence of a nickel catalyst to give the final product. Aniline undergoes very readily electrophilic substitution reactions as the aromatic ring of aniline is very electron
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EXP-10 CHEM 233L SYNTHESIS OF p-BROMOANILINE Introduction: In this experiment‚ p-bromoaniline was synthesized in three steps starting from aniline. Since the amino group of aniline is a strong activator of aromatic ring‚ direct bromination is impractical (equation 1). In order to make a desired product‚ amino group needed to be protected as the acetamide which also maintained ortho and para position but slowed down the rate of reaction (equation 2). Slow reaction rate would increase
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experiment was to illustrate electrophilic aromatic substitution by synthesizing p-nitroanilide (as well as ortho) from acetanilide by nitration. The para form was separated from the ortho form based on solubility properties using recrystallization techniques. Synthetic equations: Physical Properties & Hazards of Reagents/Products: (all taken from Sigma-Aldrich website) Acetanilide MM = 135.16 g/mol Melting point = 113-115°C Hazards: acute toxicity Sulfuric acid MM = 98.08 g/mol Boiling
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In the first part of this experiment acetic anhydride was used to prepare acetanilide which could then be readily brominated to form a mono-brominated product‚ with the bromine positioned at either the ortho‚ meta or para position on the aromatic ring. Acetic anhydride is very reactive towards nucleophiles and this reactivity is the result of the difference in electronegativities of the carbon and oxygen atoms that are bonded in acetic anhydride. This difference in electronegativities causes one
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[19593 Organic Chemistry of the Tramition Elements. Part r. View Online 551 Downloaded by University of Washington on 01 February 2011 Published on 01 January 1959 on http://pubs.rsc.org | doi:10.1039/JR9590000551 113. The Organic Chemistry of the Transition Elements. Part I. Tricarbonylchromium Derivatives of Aromatic Compounds. By B. NICHOLLS M. C. WHITING. and Many aromatic compounds‚ ArH‚ displace carbon monoxide from chromium hexacarbonyl with the formation of complexes Cr(CO)
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Since mammals do not synthesize their own folic acid‚ PABA inhibitors such as sulfanilamide selectively kill bacteria without injuring the host (Figure 1). One of the most well-known preparation techniques of sulfanilamide is achieved by treating aniline with excess chlorosulfonic acid via replacement of hydrogen with a sulfonyl chloride group. This reagent forms sulfonic acid first before being converted into a sulfonyl chloride by the excess chlorosulfonic acid (Scheme 1). A key method of sulfanilamide
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different substituted benzenes towards bromination will be determined‚ where bromine is dissolved in acetic acid. Materials and apparatus Test solutions: 0.2 M solutions in ethyl acetate: Benzene‚ chlorobenzene‚ phenol‚ nitrophenol‚ aniline and acetanilide. Measuring pipettes (5 mL) micro test tubes 0.05 M Br2 in 90% CH3COOH Pasteur pipettes 0.05 M Br2 in cyclohexane II. Schematic Diagram of the Procedure Relative Rates of Bromination Add 2 drops
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