mixture through extraction and separation methods. 2. To learn how to purify by recrystallization‚ how to dry them and how to obtain a melting point. PRECAUTION: ACETANILIDE AND PHENACETIN ARE EYE AND SKIN IRRITANTS. Minimize contact with your unknown compound. THEORY: In this experiment‚ Panacetin‚ a pharmaceutical preparation will be separated from its components by making use of their solubilities and acid-base properties. Panacetin contains aspirin‚ sucrose and an unknown component
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the chemical components of Excedrin and Tylenol‚ two common‚ over-the-counter analgesic drugs‚ were determined by utilizing the technique of thin-layer chromatography‚ or TLC. The active ingredients of Excedrin were caffeine‚ acetaminophen‚ and aspirin with Rf values of 0.11‚ 0.38‚ and 0.61‚ respectively. The lone active ingredient of Tylenol was acetaminophen with an Rf value of 0.39. The elution sequence obtained in the experiment is as follows: ibuprofen (least polar)‚ acetylsalicylic acid‚ acetaminophen
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is the separation of two or more compounds or ions caused by their molecular interactions with two phases – one moving and one stationary (Weldegirma 2012). Three types of chromatography are used in organic chemistry: Thin Layer Chromatography (TLC)‚ Gas Chromatography (GC)‚ and Column Chromatography (CC). TLC stationary phase is a solid while the mobile phase is liquid. GC stationary phase is liquid and its mobile phase is liquid. CC is one of the most useful methods for the separation and purification
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of the Unknown Analgesic Jessica Bajao*‚ Phoebe Abalos‚ Kevin Antiga‚ Carmelus Aseneta 3-Biology 2 College of Science‚ University of Santo Tomas‚ Manila‚ Philippines Abstract The group used five different analgesics in this experiment: aspirin‚ acetaminophen‚ ibuprofen‚ caffeine‚ and mefenamic acid. Six analgesics were spotted on the TLC plate including the unknown. After the development of the TLC plate‚ it was placed under ultraviolet light for the spots resulted to be traced. The distance
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to contain aspirin‚ acetaminophen‚ and sucrose; therefore‚ the tablets tested‚ containing aspirin and sucrose‚ are thought to contain an unknown of something similar to that of acetaminophen such as acetanilide or phenacetin. Another problem trying to be sought out in the experiments is whether or not the composition of Panacetin as stated on the label is accurate. The experiment involved the separation of the unknown from the Panacetin by first isolating the sucrose and the aspirin. This process
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Melting point 1. What two effects do impurities have on the melting point of an organic compound? Soluble impurities affect the melting point of a solid in the following manner. a. The presence of an impurity in the molten compound reduces its vapor pressure thus lowering the melting point of the compound. b. Broaden the melting point range. 2. For what tow purpose are melting points routinely used a. To determine the identity of an organic solid. b. To determine the purity of an organic solid
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a TLC analysis of analgesics to figure out their main chemical components. Calculations: 1.) Rf = Distance spot traveled/ distance solvent traveled Results: Table 1: TLC Analysis Analgesic Drugs | Rf Value | Acetaminophen | 0.323 | Aspirin | 0.597 | Caffeine | 0.081 | Unknown 154 (Plate 1) | 0.081‚ 0.306‚ 0.597 | Ibuprofen | 0.698 | Salicyclamide | 0.587 | Unknown 154 (plate 2) | 0.079‚ 0.397‚ 0.587 | Discussion: The goal of this experiment was to use TLC Analysis to
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point‚ boiling point‚ density‚ solubility‚ and hazards of all pertinent chemicals used in the experiment. Data/Observations: Your observations of the experiment‚ a. Weight of initial panacetin sample. b. Weight of sucrose collected. c. Weight of aspirin collected. d. Weight of unknown compound isolated e. Weight of recrystallized unknown compound f. Melting point range of recrystallized unknown compound. g. TLC sketches with appropriate data for Rf calculations (Clearly label each column of spots
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schemes using Dipotassium phosphate (K2HPO4) and Potassium hydroxide (KOH) to isolate the compounds of pure Acetylsalicylic Acid/Aspirin and N-(4-hydroxyphenyl) Ethanimidate/Acetaminophen respectively from Excedrin. The first reaction scheme to undergo acid-base organic extraction was to isolate the most acidic compound in Excedrin with a weak base‚ K2HPO4. We isolated the aspirin using aqueous base extraction‚ with Dipotassium phosphate then treated with HCl to force acidification. The mechanism for Scheme
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Panacetin‚ is originally produced by. Extraction of the chemicals Sucrose‚ Aspirin‚ and an Unknown substance is tested to determine the legitimacy of the label and drug. Theory: The percent composition is calculated for accuracy and to conclude the “label is accurate”. The formula for the percent composition is adding the sums of all the extracts‚ then dividing the total sum by each of the three (3) individual extract; Sucrose‚ Aspirin‚ Unknown. By separating
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