INTRODUCTION: Penicillin is the basis for most of the antibiotics in the world just as aspirin is the basis for many drugs. Therefore‚ if there had been only two drugs to invent‚ it would be down to penicillin and aspirin. Hippocrates‚ the father of modern medicine lived sometime between 460 B.C and 377 B.C. Hippocrates has left historical records of pain relief treatments‚ including the use of a powder made from the bark and leaves of the willow tree to help heal headaches‚ pains and fevers.
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effects for some people‚ yet it is safe enough to be sold without a prescription. Because it is easy to prepare‚ aspirin is one of the most inexpensive drugs available. It is produced in vast amounts. In fact‚ industry makes 43‚000‚000 pounds of the drug every year. This microscale experiment will permit you to make an amount of aspirin equivalent to about 1/2 of that found in an aspirin tablet. Purpose: To synthesize acetylsalicylic acid on a microscale basis. Equipment / Materials: |salicylic
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Cisplatin Resources 1. M. H. Hanigan and P. Devarajan‚ “Cisplatin nephrotoxicity: molecular mechanisms‚” Cancer Therapy‚ vol. 1‚ pp. 47–61‚ 2003. 2. Santiago Gómez-Ruiz‚ Danijela Maksimović-Ivanić‚ Sanja Mijatović‚ and Goran N. Kaluđerović‚ “On the Discovery‚ Biological Effects‚ and Use of Cisplatin and Metallocenes in Anticancer Chemotherapy‚”Bioinorganic Chemistry and Applications‚ vol. 2012‚ Article ID 140284‚ 14 pages‚ 2012. 3. N/A 4. Santiago Gómez-Ruiz‚ Danijela Maksimović-Ivanić‚ Sanja
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b. Characterization of Aspirin B. Set – up Fig. 11.1. Suction Filtration Set – up C. Table 11.1 List of Necessary Chemicals Sample Structure Purpose Physical Properties Hazards Salicylic Acid Starting Material Appearance: white powder Molar Mass: 138.12 g/mol Melting Point: 1590C Boiling Point: 2110C Density: 1.44 g/cm3 Mildly irritating (pulmonary irritants). Harmful by inhalation‚ ingestion and through skin absorption. Acetic Anhydride
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Synthesis of Aspirin Chemistry Standard Level Lab Report Data Collection and Processing and Conclusion and Evaluation Date: December 8th‚ 2011 Purpose: The purpose of this lab was to synthesize aspirin‚ determine the theoretical yield‚ compare the percent yield to the theoretical yield and test the purity of aspirin by adding Iron (III) chloride to the product. Hypothesis: I hypothesize that salicylic acid will react with acetic anhydride to produce acetylsalicylic acid (aspirin) and
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Soluble aspirin tablets Adult dosage: To treat pain or fever in adults‚ the recommended dose is 325 mg to 650 mg every 4 to 6 hours as needed. The maximum daily dose is 4‚000 mg‚ unless otherwise directed by your doctor. For adults with conditions caused by inflammation such as rheumatoid arthritis‚the usual dose is 975 mg 4 to 6 times daily on a regular basis. Sometimes‚ higher doses may be used. To treat migraine headache pain‚ the recommended adult dose is 1‚000 mg at the onset of pain or
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objective was to convert a specific amount of salicylic acid into the same amount of aspirin that was high in purity. Furthermore‚ the other objectives were to enable students to conduct the synthesis of aspirin‚ reinforce skills or recrystallisation and the technique of melting point determination. The amount of each compound should be the same because there is a 1:1 ratio between them. The purity of the synthesized aspirin was measured by determining its melting point and percent yield. Soluble impurities
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Once the aspirin is prepared‚ it is isolated from the reaction solution and then it is purified. The aspirin is insoluble in cold water‚ and it is isolated by filtering the chilled reaction solution. Purification is essential to remove any unreacted salicylic acid and acetic anhydride as well as the acetic acid product and phosphoric acid. Acetic anhydride is caused to decompose by the addition of water once the formation of aspirin is complete. C4H6O3 (Acetic anhydride) + H2O (Water) ------------------------->
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Introduction: The purpose of this lab was to learn how to use salicylic acid to make aspirin. Aspirin is the most widely used over-the-counter drug in the world. The average tablet contains about 325 milligrams of acetylsalicylic acid with an inert binding material such as starch. Aspirin is used to relieve pain‚ reduce inflammation‚ and lower fever. Aspirin originally was derived by boiling the bark of the white willow tree. Although the salicin in willow bark has analgesic properties‚ purified
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Lab 1: Synthesis of Aspirin Introduction: The purpose of this lab was to demonstrate the ability to easily alter the molecular structure of a compound to greatly increase its utility. In this case‚ an acetyl group was added to salicylic acid‚ a naturally occurring compound with significant pharmaceutical value. Without the addition of the acetyl group‚ salicylic acid is an irritant to the gastro-intestinal (GI) tract. Once the acetyl group is added via a simple reaction‚ acetylsalicylic
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