Darnell Shaw Lab Extra Credit Hippocrates of Cas (460-377 B.C.)‚ The Healer‚ noted that chewing leaves of willow (Salix) reduced pain‚ and he prescribed this remedy for women in labor. The Healer certainly did not discover this drug‚ which was used for centuries earlier in European folk medicine. Ancient Egyptians took an infusion of dried myrtle leaves to treat muscle pain. The myrtle leaves were also found to contain salicylic acid. Two Italians‚ Brugnatelli and Fontana‚ had in fact already
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EUROPEAN PHARMACOPOEIA 5.0 Acetylsalicylic acid TESTS Appearance of solution. Dissolve 1.0 g in 9 ml of alcohol R. The solution is clear (2.2.1) and colourless (2.2.2‚ Method II). Related substances. Examine by liquid chromatography (2.2.29). Prepare the solutions immediately before use. Test solution. Dissolve 0.10 g of the substance to be examined in acetonitrile for chromatography R and dilute to 10.0 ml with the same solvent. C. N‚N′-diacetyl-L-cystine‚ Reference solution (a).
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crystals 95% ethanol Clear colorless liquid Acetyl chloride Clear colorless liquid with gas escaping from container FeCl3 Clear colorless liquid Commercial aspirin Fine powdery white solid crystals I2/KI Deep black liquid KMnO4 Brownish liquid Phosphoric acid Clear colorless liquid Table 2. Preparation of Aspirin. Description Salicylic acid + Acetyl chloride Cloudy white liquid with undissolved white powder Mixture at room temp White cloudy liquid Mixture in ice bath
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to synthesise pure aspirin using chemical tests such as esterification and recrystallization independently and to also find out the melting point range of aspirin using melting point determination. INTRODUCTION Aspirin‚ which is also known as acetylsalicylic acid‚ is one of the commonly used and widely found in any drugstore or pharmacy. Its properties make aspirin a well-rounded drug that reduces inflammation and fever and also relieves pain. The active ingredient in aspirin was found to be salicylic
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to be 1.43 x 10-3‚ as shown in Equation 3. The purified aspirin product was a white powder that had a weight of .140 g. The number of moles of the purified aspirin product after extraction was 7.77 x 10-4 as shown in Equation 4. These two moles calculated a chemical yield of 54.3% as shown in Equation 5. The melting point of the pure aspirin product was ranged at 117.8-125.2C as shown in Table 1. An infrared spectrum for the pure aspirin from the synthesis was taken by using crushed crystals
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Aspirin were used to relieve pain‚ inflammation‚ and fever. Aspirin were made using a combination of salicylic acid and acetic anhydride.The goal of this experiment was to determined the purity of aspirin using different methods. These methods included‚ reacting salicylic acid with FeCl3‚ finding its melting points‚ and by doing Thin-layer chromatography. When you reacted salicylic acid with FeCl3‚ changes in color will occur. Pure Aspirin has a melting point around 135°C and a pure salicylic acid
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report discussing the purity of my aspirin sample I produced. When I carried out the experiment to produce an aspirin sample I had to take a few results I had gained from carrying out the experiment later used these to work out the experimental error and percentage % yield. The results I used where the published value of what temperature pure aspirin melts at‚ the temperature my aspirin sample melted at‚ the weight of pure aspirin and the weight of impure aspirin. Firstly I worked out the experimental
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alternative to aspirin. Such a positioning will be able to attract current aspirin customers to Datril. The marketing campaign should focus on physicians‚ trade and patients. It should stress the information of little side effects compared to other analgesic medicine. Both the retail price and the trade price should be lower than Tylenol. Segmentation and targeting: Datril should target on aspirin users. Datril potential clients could be 1) people currently using aspirin 2) people currently
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Aspirin has been a pain reliever for more than 100 years. Aspirin has been used as a remedy for many illnesses for centuries now and still more things are yet to be identified about aspirin and its uses. It was recently discovered that aspirin can be used to reduce clotting of the platelets in the blood vessels‚ thus reducing the risk of heart attack in humans. Most students in their youthful age were not able to give their heart the maximum care it deserved‚ as a result‚ it leads to heart related
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CH4300/PY5140 - EXPERIMENT 2 – Answer Sheet SYNTHESIS OF THE PHARMACEUTICAL ASPIRIN (ACETYLSALICYLIC ACID) Aim: The aim of this experiment was to react salicylic acid with ethanoic anhydride to produce Aspirin. CH3CO)2O + HOC6H4COOH → CH3CO2C6H4CO2H + CH3COOH i Mass: 5g Volume: 7.5 cm3 Mass: 6.52g RMM: 138g/mol RMM: 180g/mol Moles: 5/138 = 0.0362 RMM: 102g/mol Moles: 0.0362 OBSERVATIONS – First‚ Ethanoic acid was added to the salicylic acid which resulted
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