Increasing size of uterus
Greater pressure on blood vessels
Regurgitation of blood to cerebral vessels
Cerebral congestion
convulsions
A PICTURE OF Dr. THOMAS DENMAN
In 1849 Dr. William Tyler Smith challenged this theory because he believed
that pregnancy was a state of fullness in circulation and many cases of
Convulsions would be observed if such congestion caused convulsions.
According to him, the cause are;
• Any excessive mechanical or emotional stimulus applied to spinal
centres.
• Blood letting
• Variations in atmosphere, wind and temperature
• Irritation to uterus, uterine passages and intestines
• Presence of toxins due to retention of wastes
A PICTURE OF Dr. …show more content…
Later opiates and hastening of delivery when the woman is physiologically
ready was considered by Denman.
With theory of disease causation focus shifted on microbes.
DISEASE CLASSIFICATION:
Bossier de Sauvages noted sever hemorrhage, various sources of pain and
vermicular infestations associated with eclampsia.
In 1797 Demanet noted association between edema and eclampsia.
In 1843 John Lever discovered albumin in urine of eclamptic women.
In 1843 Dr. Robert John described the imminent symptoms of eclampsia like
headache, temporary loss of vision, severe stomach pain, edema of hands, neck
and face.
As a result of these contributions the concept of preeclamptic state was identified.
A PICTURE DESCRIBING “PREECLAMPTIC STATE” 20TH CENTURY:
THEORIES ON DISEASE CAUSATION:
Although the researches failed to identify the etiology, the pathophysiology was better understood.In 1960, dramatic difference in placenta of preeclampsia and a normal one was identified.
It was discovered that placental trophoblasts failed to invade the uterine spiral arteries in preeclampsia, causing VASOSPASM AND PLACENTAL …show more content…
• STAGE 2: The maternal syndrome is characterized by occlusive
• microthrombi affecting multiple organs, hypertension, proteinuria
and Edema
3. PLACENTAL TOXINS ( cytokines ,angiogenic factors etc ) are not
tolerated by some women leading to preeclampsia.
The following picture shows these theories :
Diagnosis of Hypertension:
DEFINITION OF HYPERTENSION IN PREGNANCY
• Systolic BP more than or equal to140 mmHg
• Diastolic BP of more than or equal to90 mmHg
Atleast two measurements,should be taken,in the same arm, 6 hours apart but with in a weak period and the average should be considered. High systolic and diastolic BP have been associated with adverse foetal and maternal outcome .
Identifying increase in blood pressure from booking or preconception blood pressure, instead of relying on absolute value, was considered useful in diagnosing preeclampsia in the past . Now close monitoring of that pt will be appropriate. Measurement of Proteinuria:
All pregnant women must be checked for proteinuria. Urinary dipstick testing might be used for screening patients for proteinuria (due to easy availability
,convenience and low cost.)
Grading for proteinuria is:
Trace .15 to