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Effects of Antibiotics in Humans

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Effects of Antibiotics in Humans
Author: Jennifer Tanksley
Instructor: Dr. James E Ayers
Course Number: 102
Date: February 5, 2012

The advantages and disadvantages of Antibiotic usage in Humans

Since the discovery of antibiotics and their usefulness in therapeutic interventions, they

have risen to prominence owing to their ability to improve the quality of life through the

treatment and management of a wide array of diseases of bacterial aetiology. An

Antibiotic is a compound or substance that kills or slows down the growth of bacteria.

Antibiotics are powerful drugs for disease management making them fundamental

alternatives for the prolongation of the natural span of life. Antibiotics have unquestionably

saved more lives than any other drug ever discovered by man. However, it does not

necessarily imply that antibiotics do not possess the flip side. It has been demonstrated that

antibiotics indiscriminately wipe out both normal and abnormal gastrointestinal and vulvo-

vaginal flora. Human overuse as well as the widespread use of antibiotics has been

responsible for the co-resistance and cross resistance to multiple antibiotics. This paper is a

concise exposition of the effects of prolonged usage and the pro 's and con 's of antibiotics in

humans.

Currently, after decades of overuse in human medicine the threat of antibiotic

resistance has become a reality. Resistance in certain species of antibiotics has been

attributed to inadequate and inappropriate use of antibiotic drugs (Andersson 2005).

Through resistance genes strains of bacteria are becoming more and more resistant to drugs

in everyday usage. The transfer of antibiotic resistance from one bacterial species to another

is a real threat to the continued efficacy of antibiotics in the treatment and management of

diseases of bacterial aetiology. The inevitability of antibiotic resistance is driven by the

injudicious and indiscriminate prescription of



References: Andersson, D. I. (2005). The ways in which bacteria resist antibiotics. International Journal of Risk & Safety in Medicine. 17: 111-116. Briet, F., Pochart, P., Marteau, P., Flourie, B., Arrigini, B., & Rambaud, J. (1997). Improved clinical tolerance to chronic lactose ingestion in subjects with lactose intolerance: a placebo effect. GUT; 41: 632-635. BMJ Publishing Group Ltd & British Society of Gastroenterology. Esminger, A. (1994). Foods and Nutrition Encyclopedia: A To H. 2nd Edition. CRC Press; 96-98. He, T., Priebe, M. G., Harmsen, H. J. M., Stellaard, F., Sun, X., Welling, G. W., Vonk, R. J. (2006). Colonic Fermentation may play a role in lactose intolerance in humans. Nutrient Physiology, Metabolism, and Nutrient-Nutrient Interactions. American Society for Nutrition. J. Nutr. 136:58-63 Kilkkinen A, Rissanen H, Klaukka T. (2008). Antibiotic use predicts an increased risk of cancer. Int. J. Cancer; 123(9):2152-5. Kramer, M. S., Hutchinson, T. A., Naimark, L., Contardi, R., Flegel, K. M., Leduc, D. G. (1985). Antibiotic-Associated Gastrointestinal Symptoms in General Pediatric Outpatients. Pediatrics, 76(3): 365-370 Martinez, J. L (18 July 2008). Antibiotics and Antibiotic Resistance Genes in Natural Environments. Science. Vol. 321. www.sciencemag.org Preidt, R. (2008). Long-Term Antibiotic Use Affects 'Good ' Gut Bacteria. Healthday Consumer News Service, 11/19/2008; http://web.ebscohost.com/ Want. S. V., & Holmes, A. (1999). Antibiotic resistance and the new antibiotic agents. Review Paper. Clinical Intensive Care 10: 211-218 Wilson, M. (2005). Microbial inhabitants of man: their ecology and role in health and disease. Cambridge University Press; 303-308.

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