Goodpasture's Syndrome

Goodpasture’s syndrome is characterized by severe necrosis of the glomerulus triggered by an antibody that reacts with glycoprotein in the glomerular basement membrane. The result is glomerulonephritis, in which immune deposits accumulate and complement fixation causes injury to the tissue, eventually producing renal failure. This antibody can also react with basement membrane in lung tissue, producing pulmonary hemorrhage.

Goodpasture syndrome can results from an antecedent infection of the throat caused by a nephritogenic strain of group A beta-hemolytic streptococci.
These strains of streptococci have protein M and protein T in their bacterial cell wall.
The protein M results to an immunologic reaction which results to an autoimmune disorder