Intentional Hypothermia Research

Intentional hypothermia Controlled hypothermia plays important role in reducing the oxygen consumption by the body. This step used with Jehovah’s Witnesses since they reject the transfusion. As the body temperature reduced by 5-7°C, the oxygen consumption reduced as well by 48% beneath the basic levels and increased in the blood. However, the reduction in body temperature below 30°C requires the clinician to monitor the patient to make sure that the patient did not suffer from hypothermia. Even though hypothermia increases the attraction between hemoglobin and oxygen, it does not weaken tissue oxygen extraction (Kiran et al, 2014).
Control hypotension Controlled low blood pressure is another way of reducing blood loss. This method is done by reducing the cardiac output or systemic vascular resistance (Kiran et al, 2014). Hypotension can result from taking specific types of medications such as isoflurane (inhaler), propofol, and nitroglycerin
(vasodilator)
Hemostatic agents There are several agents used to minimize the blood loss such as aprotinin, antifibrinolytics, and desmopressin.
Aprotinin inhibits serine protease and reduces blood loss. However, aprotinin has side effects on heart and renal functions. Therefore, it is usage has been restricted to trial purposes solely (Kiran et al, 2014). Antifibrinolytics is the most commonly used to reduce blood loss. It is a mixture of aprotinin and lysine analogous (tranexamic acid and ε-aminocaproic acid). Tranexamic acid and ε-aminocaproic acid inhibited the plasmin that mediate the fibrin breakdown. In other words, they halt the plasminogen from converting into plasmin, which then the plasmin activate the fibrinolysis. Desmopressin is a compound similar to vasopressin. It triggers the production of Von Willebrand factor and factor VIII, which activate the platelets aggregation. Therefore, desmopressin used to treat Von Willebrand disease and hemophilia. That means the desmopressin can be used to halt the
bleeding.
Post-Operative Control Patient in this stage needs close monitoring for any sign of bleeding or anemia. This step is done by assuring that the patient has adequate oxygen level, administering antifibrinolytics agent or any other hemostatic agents, restricting the phlebotomy, and promoting erythropoiesis in case of anemia. Additionally, the healthcare provider can use the cell salvage and maintain the normal blood volume to adjust anemia and blood loss.