Klinefelter Syndrome Research Paper

Klinefelter syndrome is an additional X chromosome in the cells affecting males. Meiotic nondisjunction is the major result of this syndrome. There are differences in the degree of severity of physical, language, and behavioral development symptoms between affected individuals. Klinefelter syndrome is not passed from parent to child; even though, women who have pregnancies after the age of 35 may have an increased chance of having a boy with the presence of extra sex chromosome. Tests for chromosome disorder before birth will eliminate influences in quality of life.
Sex chromosomes in females normally are one X and one Y chromosome. Therefore, male would have 44 autosomes and the X and Y sex chromosomes, making a complete set of 46 chromosomes in the nucleus; this is written as 46, XY which is expressed that individual’s karyotype. In 1942, Dr. Klinefelter from Massachusetts General Hospital in Boston published the report about the condition on nine males who had breast enlargement, reduced body and facial hair, reduced muscle mass, small testes, and infertility. Klinefelter syndrome, also called XXY trisomy or 47, XXY, was firstly described and is
A pair of sex chromosomes does not correctly divide during parental gametogenesis that leads to meiotic nondisjunction. When an egg or sperm gains with a normal sperm or egg, an embryo comes up with the extra copied chromosome to form three sex chromosomes XXY. Meiotic nondisjunction highly occurs in the mother by two factors, such as meiosis I errors and maternal age. The mosaicism is also cause by meiotic nondisjunction after fertilization of the zygote but the extra X chromosome is in only some of the cells. Klinefelter syndrome is a random genetic disorder or a random error in early egg development; thus, 47, XXY and mosaic 46, XY/47, XXY are not inherited but they are