Micro
4/16/14 Biology 260
Host Defenses V
Outline
Self and non-self
Play distinct and significant role in detection, recognition, and cell communication.
MAJOR FUNCTIONS:
Perceive and attach to nonself or foreign antigens
Promote the recognition of self-antigens
Receive and transmit chemical messages among other cells of the system
Aid in cellular development
Major histocompatibility complex (MHC) proteins = Human Leukocyte (HLA) Antigens, set of genes that codes for human cell receptors, gives rise to a series of glycoproteins found on all cells except RBCs.
Plays a vital role in recognition of self by the immune system and in rejection of transplanted tissues.
Two classes
Class I MHC, genes code for markers that display unique characteristics of self and allow for the recognition of self-molecules and the regulation of immune reactions.
Found on all nucleated RBCs
The closer the relationship, the greater the probability for similar MHC probabilities, highly unlikely to be identical.
Blood transfusions, don’t have to worry if compatible.
Class II MHC, genes code for immune regulatory receptors.
Antigen presenting cells APCs, macrophages, dendritic cells and B cells.
Have two sets, so the more closely related two people are, the more proteins that will be the same organ donating (KIDNEYS, Kathryn’s mom)
Have both MHCI and MHC II receptors necessary for interactions with T cells.
Immunosuppression, Maggie, to get sick very easily.
More proteins shared, less immunosuppression, why interest in growing human stem cells.
Antigens, any molecule or fragment of a molecule that has the POTENTIAL to trigger a specific immune response by lymphocytes. Antibody generating substance.
Immunogen, a type of antigen that actually DOES induce a specific immune response.
Immune cells act to antigen as nonself or as foreign
Poor immunogens, small molecules not attached to a carrier molecule (hapten).
Whole cells and viruses make good immunogens,
Host Defenses V
Outline
Self and non-self
Play distinct and significant role in detection, recognition, and cell communication.
MAJOR FUNCTIONS:
Perceive and attach to nonself or foreign antigens
Promote the recognition of self-antigens
Receive and transmit chemical messages among other cells of the system
Aid in cellular development
Major histocompatibility complex (MHC) proteins = Human Leukocyte (HLA) Antigens, set of genes that codes for human cell receptors, gives rise to a series of glycoproteins found on all cells except RBCs.
Plays a vital role in recognition of self by the immune system and in rejection of transplanted tissues.
Two classes
Class I MHC, genes code for markers that display unique characteristics of self and allow for the recognition of self-molecules and the regulation of immune reactions.
Found on all nucleated RBCs
The closer the relationship, the greater the probability for similar MHC probabilities, highly unlikely to be identical.
Blood transfusions, don’t have to worry if compatible.
Class II MHC, genes code for immune regulatory receptors.
Antigen presenting cells APCs, macrophages, dendritic cells and B cells.
Have two sets, so the more closely related two people are, the more proteins that will be the same organ donating (KIDNEYS, Kathryn’s mom)
Have both MHCI and MHC II receptors necessary for interactions with T cells.
Immunosuppression, Maggie, to get sick very easily.
More proteins shared, less immunosuppression, why interest in growing human stem cells.
Antigens, any molecule or fragment of a molecule that has the POTENTIAL to trigger a specific immune response by lymphocytes. Antibody generating substance.
Immunogen, a type of antigen that actually DOES induce a specific immune response.
Immune cells act to antigen as nonself or as foreign
Poor immunogens, small molecules not attached to a carrier molecule (hapten).
Whole cells and viruses make good immunogens,