Misregulation In Human Development

Growth is a very important aspect of development of human, influenced both by environmental factors, such as nutrition and infectious diseases, and by intrinsic factors, such as hormones, growth factors and a variety of additional genetic factors [1] and is affected with many genes. Growth failures are caused by a disruption of one of the pathways involved in growth regulation [2,3]. Misregulation in this process can lead to disproportionate or proportionate short stature or various skeletal dysplasias [4].
Short stature is a developmental, multifactorial condition with a strong genetic component. Two to three percent of the children in the world have short stature [5] and in 80% of the cases, there is no history of small for gestational age,