Nicotinic Receptors

These receptors are present in different locations, have different mechanisms of signal transduction, and also have different functions. Nicotinic receptors are present in the central nervous system (CNS), somatic nervous system (neuromuscular junction) and both sympathetic and parasympathetic autonomic ganglia. Binding of ACh to these receptors leads to influx of sodium ion and depolarization. Muscarinic receptors are found in the CNS, at the parasympathetic nervous system (cardiac conduction system, smooth muscles and exocrine gland), sympathetic nervous system (sweat gland) and prejunctionally at the neuromuscular