Phencyclidine Research Paper
Phencyclidine, otherwise known as PCP, Angel Dust, Hog, Peace Pill, Cliffhanger, Happy Sticks, is a dissociative anesthetic or hallucinogen . Users of this drug seem to be "disconnected" from the world around them. It messes perceptions of sight, sound and produces feelings of detachment. Instead of visually hallucinating , PCP causes its user to experience distortions of reality. PCP is a white crystal like powder that can easily be dissolved in water or alcohol. This drug can be eaten, injected, snorted, or smoked. The effects and longevity of the effects is determined by how the drug is taken in and the dosage. If a low dosage is taken a user may have feelings of euphoria, relaxation, numbness, sensory distortions, feelings of detachment
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This is an anesthetic that work to is antagonize, or inhibit the action of, the N-Methyl-D-aspartate receptor. The anesthesia that is induced is referred to as dissociative anesthesia. There is evidence that NMDA receptor antagonists can cause a certain type of brain damage, referred to as Olney's Lesions in rodents, but this type of damage has not yet been found in adult humans. Although NMDA antagonists were once thought to cause neurotoxicity in humans, for example Olney's lesions, recent research suggests otherwise. Olney's lesions involve mass vacuolization of neurons observed in rodents. However, this is not a valid for human use, and studies conducted on primates have shown that use of NMDA receptor antagonist drugs must be heavy and chronic to cause major neurotoxicity. Although, temporary and permanent cognitive impairments have been found in long-term/heavy human users of the NMDA antagonists PCP and ketamine. An NMDA receptor antagonists depletes the NMDA receptors. Depleted NMDA receptor function is associated with a variety of negative effects. For example, NMDA receptor hypofunction that occurs as the brain ages may be partially responsible for memory deficits associated with aging. Schizophrenia may also have to do with irregular NMDA receptor function. Because of these psychotomimetic effects, NMDA receptor antagonists, like PCP are used as recreational drugs. Another way according to the NIDA that
This is an anesthetic that work to is antagonize, or inhibit the action of, the N-Methyl-D-aspartate receptor. The anesthesia that is induced is referred to as dissociative anesthesia. There is evidence that NMDA receptor antagonists can cause a certain type of brain damage, referred to as Olney's Lesions in rodents, but this type of damage has not yet been found in adult humans. Although NMDA antagonists were once thought to cause neurotoxicity in humans, for example Olney's lesions, recent research suggests otherwise. Olney's lesions involve mass vacuolization of neurons observed in rodents. However, this is not a valid for human use, and studies conducted on primates have shown that use of NMDA receptor antagonist drugs must be heavy and chronic to cause major neurotoxicity. Although, temporary and permanent cognitive impairments have been found in long-term/heavy human users of the NMDA antagonists PCP and ketamine. An NMDA receptor antagonists depletes the NMDA receptors. Depleted NMDA receptor function is associated with a variety of negative effects. For example, NMDA receptor hypofunction that occurs as the brain ages may be partially responsible for memory deficits associated with aging. Schizophrenia may also have to do with irregular NMDA receptor function. Because of these psychotomimetic effects, NMDA receptor antagonists, like PCP are used as recreational drugs. Another way according to the NIDA that