Probiotics
Probiotics and clinical effects: is the number what counts?
Bertazzoni E, Donelli G, Midtvedt T, Nicoli J, Sanz Y.
Source
Department of Public Health and Community Medicine, Pharmacology Section, Policlinico 'G. B. Rossi ', Verona, Italy.
Abstract
Probiotics are defined as 'live microorganisms that when administered in adequate amounts confer health benefits on the host ', underlining the need of microbial viability and the requirement of a suitable dose to obtain a health benefit. The dose and the administration regimen are critical issues forprobiotics either ingested as foods claiming health benefits or used as drugs in clinics. In fact, regulatory authorities demand to guarantee consumers that a probiotic is effective in the recommended conditions of use and responds to its specific claims. Thus, a proper identification of probiotic strain(s), a definition of the amount of microorganisms surviving by the end of the product shelf-life, and a demonstration of their beneficial effects by appropriate human trials are required. The current knowledge on the effective dose of different probiotic strains used for several disorders is here reviewed.
Too fast, too soon to call it "probiotic".
Miniello VL, Colasanto A, Diaferio L, Galizia IS, Jablonska J, Lauriero MA, Lieggi MS, Raimondi G, Santoiemma V, Sarcinella G, Simone R, Torrente P.
Source
Clinica Pediatrica Salvatore Maggiore, Dipartimento di Biomedicina dell 'Età Evolutiva, Università degli Studi di Bari.
Abstract
Probiotics (bacteria or yeasts) were defined by the Food Agricultural Organization (FAO) and the World Health Organization (WHO) joint report as live microorganisms which when administered in adequate amounts (in food or as a dietary supplement) confer a health benefit on the host. The best-demonstrated potential clinical benefits of probiotic agents, specifically in the pediatric population, are in the prevention and management of acute diarrhea, antibiotic associated diarrhea, and
Bertazzoni E, Donelli G, Midtvedt T, Nicoli J, Sanz Y.
Source
Department of Public Health and Community Medicine, Pharmacology Section, Policlinico 'G. B. Rossi ', Verona, Italy.
Abstract
Probiotics are defined as 'live microorganisms that when administered in adequate amounts confer health benefits on the host ', underlining the need of microbial viability and the requirement of a suitable dose to obtain a health benefit. The dose and the administration regimen are critical issues forprobiotics either ingested as foods claiming health benefits or used as drugs in clinics. In fact, regulatory authorities demand to guarantee consumers that a probiotic is effective in the recommended conditions of use and responds to its specific claims. Thus, a proper identification of probiotic strain(s), a definition of the amount of microorganisms surviving by the end of the product shelf-life, and a demonstration of their beneficial effects by appropriate human trials are required. The current knowledge on the effective dose of different probiotic strains used for several disorders is here reviewed.
Too fast, too soon to call it "probiotic".
Miniello VL, Colasanto A, Diaferio L, Galizia IS, Jablonska J, Lauriero MA, Lieggi MS, Raimondi G, Santoiemma V, Sarcinella G, Simone R, Torrente P.
Source
Clinica Pediatrica Salvatore Maggiore, Dipartimento di Biomedicina dell 'Età Evolutiva, Università degli Studi di Bari.
Abstract
Probiotics (bacteria or yeasts) were defined by the Food Agricultural Organization (FAO) and the World Health Organization (WHO) joint report as live microorganisms which when administered in adequate amounts (in food or as a dietary supplement) confer a health benefit on the host. The best-demonstrated potential clinical benefits of probiotic agents, specifically in the pediatric population, are in the prevention and management of acute diarrhea, antibiotic associated diarrhea, and
References: * AlFaleh KM, Bassler D. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database of Systematic Reviews. 2008;(1):CD005496. Accessed at www.thecochranelibrary.comon February 15, 2011. * Allen SJ, Martinez EG, Gregorio GV, et al. Probiotics for treating acute infectious diarrhoea. Cochrane Database of Systematic Reviews. 2010;(11):CD003048. Accessed at www.thecochranelibrary.comon February 15, 2011. * American Academy of Microbiology. Probiotic Microbes: The Scientific Basis. Report from a colloquium held in Baltimore, MD, November 5–7, 2005. Washington, DC: American Academy of Microbiology; 2006.