Reaction Paper On Paclitaxel (PTX)
Paclitaxel (PTX)
Paclitaxel (PTX), a member of taxane family, it’s an effective antineoplastic agent for treatment of many forms cancer. The success of PTX in these diseases due to a broad spectrum of antitumor activity, efficacy in terms of dense disseminated tumours and a unique mechanism of action. This microtubule-stabilizing drug selectively disrupts the microtubule forces, which induces mitotic arrest that leads to cell death(Bernabeu et al. 2017). A brief run through of its development from research
In 1960, the National Cancer Institute (NCI, USA) in conjunction with the US department of agriculture (USDA), cooperated on plant screening programme with the aim of finding effective new anticancer properties. Of the fifteen thousand plants examined, 115 000 extracts were tested.
1962 saw Pacific yew’s bark, Taxus brevifolia, collected by botanists located in the national forest, Washington state. In 1965, the crude extract belonging to the yew’s bark was fractionated frequently by scientists from the natural products laboratory. There they identified the responsible active ingredient for cytotoxicity activity which they denoted, Taxol. …show more content…
When the compound was subsequently exploited commercially as a drug, Taxol was registered as a trademark. Accordingly, the generic name paclitaxel has been assigned to the compound. The literature now encompasses an unfortunate mixture of the two names, though the original name taxol is most often used. Taxus brevifolia (Taxaceae), a slow growing shrub/tree found in the forests of North-West Canada (British Columbia) and the USA (Washington, Oregon, Montana, Idaho, and North California) (Dewick,
Paclitaxel (PTX), a member of taxane family, it’s an effective antineoplastic agent for treatment of many forms cancer. The success of PTX in these diseases due to a broad spectrum of antitumor activity, efficacy in terms of dense disseminated tumours and a unique mechanism of action. This microtubule-stabilizing drug selectively disrupts the microtubule forces, which induces mitotic arrest that leads to cell death(Bernabeu et al. 2017). A brief run through of its development from research
In 1960, the National Cancer Institute (NCI, USA) in conjunction with the US department of agriculture (USDA), cooperated on plant screening programme with the aim of finding effective new anticancer properties. Of the fifteen thousand plants examined, 115 000 extracts were tested.
1962 saw Pacific yew’s bark, Taxus brevifolia, collected by botanists located in the national forest, Washington state. In 1965, the crude extract belonging to the yew’s bark was fractionated frequently by scientists from the natural products laboratory. There they identified the responsible active ingredient for cytotoxicity activity which they denoted, Taxol. …show more content…
When the compound was subsequently exploited commercially as a drug, Taxol was registered as a trademark. Accordingly, the generic name paclitaxel has been assigned to the compound. The literature now encompasses an unfortunate mixture of the two names, though the original name taxol is most often used. Taxus brevifolia (Taxaceae), a slow growing shrub/tree found in the forests of North-West Canada (British Columbia) and the USA (Washington, Oregon, Montana, Idaho, and North California) (Dewick,