Introduction
Tulsi is classified as Surasadigana in Ayurveda. The plant grows throughout India but is widely cultivated in home gardens. The medicinal use Tulsi is not mentioned in Ayurveda but it figures in the traditional medical systems such as Greek, Roman, Sidha and Unani.
Tulsi belongs to the family Lamiaceae. Other Sanskrit synonyms include Apetarakshasi, Bahumanjari, Bhutghani, Gauri, Haripriya, Surasa, and Tulasi. In English it is known as Holy basil.
O. sanctum is an upright, plant covered with soft hairs. The stems are square in soft, and the leaves have serrated leaf margins. The flowers are purplish in colour. Seeds are flat and reddish or yellow with minute black spots.
Chemically tulsi contains …show more content…
Kelm, Nair, Strasburg and DeWitt (2000) reported in vitro antioxidant activity of six phenolic compounds isolated from O. sanctum (eugenol, rosmarinic acid, apigenin and three other flavonoids).
6. Balanehru and Nagarajan (1991) reported antioxidant activity of ursolic acid isolated from O. sanctum against lipid peroxidation in liver microsomes in vitro.
7. Karthikeyan, Ravichandran and Govindasamy (1999) reported chemopreventive effect of O. sanctum on DMBA-induced hamster buccal pouch carcinogenesis.
8. Godhwani, Godhwani, Vyas (1987) studied anti-inflammatory, analgesic and antipyretic activity of O. sanctum in animals.
9. Chattopadhyay (1993) reported hypoglycemic effect of O.sanctum leaf extract in normal and streptozotocin diabetic rats.
Clinical trial in diabetes mellitus
Agrawal, Rai and Singh (1996) in a randomized placebo-controlled, single blind trial studied the effects of dried leaf of O. sanctum in a dose 2.5 g daily on fasting and postprandial blood glucose and hyperlipidemic patients. Forty patients, (twenty taking oral hypoglycemic agents and twenty with newly diagnosed and not taking any antidiabetic medication) were screened for the study. They were directed to consume 2.5 g of O. sanctum leaf or placebo in water on empty stomach. At the end of the study it was concluded that O. sanctum has significant hypoglycemic and hypolipidemic