May 22‚ 2012 Name: Cristhian Valor Organic Laboratory Pre-Lab 1. Main reaction sequence including side reaction products: 2. 3 Sentence Summary of the Experiment: The OH group on the benzene ring in salicyclic acid reacts with acetic anhydride to form an ester functional group. Thus the formation of acetylsalicyclic acid (aspirin) is referred to as an esterification reaction‚ which requires the presence of H+ (H2SO4 in our case). The technique used to purify the aspirin content is
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C – OH + HO – CH3 – C – O– + H2O Acetic acid Salicylic acid Aspirin (containing an (acetylsalicylic acid‚ -OH group) an ester) The use of acetic anhydride instead of acetic acid‚ however‚ is a better preparative method‚ because the anhydride with the water to form acetic acid tends to drive the reaction to the right as shown below. An acid catalyst also is used to speed
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Acetylsalicylic Acid (Aspirin) Synthesis Telow‚ AJV Sumicad‚ CJ‚ Tavanlar‚ EMMT‚ Chem 40.1‚ Institute of Chemistry‚ University of the Philippines Los Baños I. Introduction Organic synthesis is the process where a desired organic compound is constructed or prepared from commercially available materials. The objective of organic synthesis is to design the simplest synthetic routes to a molecule. Aspirin‚ also known as acetylsalicylic acid is as salicylate drug often used as analgesic
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In this experiment you will prepare two esters of o-hydroxybenzoic acid‚ more commonly known as salicylic acid. One of the esters‚ acetylsalicylic acid‚ is aspirin‚ the common analgesic. We will synthesize aspirin by mixing salicylic acid with acetic anhydride. The second ester product is oil of wintergreen‚ or methyl salicylate‚ which we prepare by allowing salicylic acid to react with methyl alcohol. This compound‚ which has a familiar odor is used as
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Introduction Materials Chemicals Equipment Safety Containers Measuring Devices Other Equipment Procedure Synthesis of Aspirin Crystalizing the Aspirin Recrystallizing the Crude Aspirin Finding the Melting Point Range Safety Precautions Acetic Anhydride Sulphuric and Salicylic Acid Heating Observations Mass of Aspirin Synthesized Melting Point Calculations Percentage Yield Maximum Yield Crude Product Final Product Melting Range Percentage Error Crude Product Final Product Conclusion
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Ariza Yamashita Department of Biological Sciences‚ College of Science Group 11 Corresponding author: gerome_911@yahoo.com Abstract The purpose of this experiment was to synthesize isopentyl acetate via Fischer esterification reaction between acetic anhydride and isoamyl alcohol‚ using concentrated sulfuric acid as a catalyst. This reaction is characterized by the combining of an alcohol and an acid (with an acid catalyst) to yield and ester plus water. In order to accomplish this reaction‚ the reactants
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Introduction: Acetaminophen is a commonly used analgesic‚ which is essentially just a medicine that relieves pain (Prescott‚ 2000). Acetaminophen is created by synthesizing p-Aminophenol with Acetic anhydride. This reaction occurs when the amine group of the p-aminophenol is acetylated by the acetic anhydride. The resultant is an amide functional group (Ellis‚ 2002). However‚ the product that is obtained from this product is a crude solid which cannot be used as an analgesic and therefore the crude
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β-D-Glucose Pentaacetate from its Original D-Glucose and it comparison with literature though Melting point‚ TLC‚ IR‚ 1H and 13C NMR Abstract: The synthesis of the product: β-D-glucose pentaacetate is done though the acetylation using acetic anhydride with D-glucose with the help of sodium acetate. The recrystallization of the product is done though a polar solvent like water. The Result of this experiment has a percentage yield of 61% and analytical methods that are to detect the products
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Aspirin were used to relieve pain‚ inflammation‚ and fever. Aspirin were made using a combination of salicylic acid and acetic anhydride.The goal of this experiment was to determined the purity of aspirin using different methods. These methods included‚ reacting salicylic acid with FeCl3‚ finding its melting points‚ and by doing Thin-layer chromatography. When you reacted salicylic acid with FeCl3‚ changes in color will occur. Pure Aspirin has a melting point around 135°C and a pure salicylic acid
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glass Thermometer Filter paper 600 ml Beaker Large test tubes Hot plate Funnel Chemicals Acetic anhydride 1% Ferric Chloride Solution Salicylic Acid Ice Ethanol Methyl Alcohol Concentrated Sulfuric Acid Distilled Water Procedure Synthesis of Aspirin 1. Place 3 grams of Salicylic acid in a Erlenmeyer flask and record the mass 2. Add 6 ml of Acetic anhydride to the flask of salicylic acid 3. Add 5 drops of concentrated sulfuric acid to the flask of salicylic
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