Bcl-2 Protein Analysis
Bcl-2 protein has two main protective functions; first it regulates Ca2+ release from the endoplasmatic reticulum by directly interacting with the inositol 1,4,5-triphosphate receptor. Second, it acts as a sensor for the redox status of mitochondria by detecting and regulating the mitochondrial glutathione pool.
Evidences have shown that Bcl-2 protects neural cells from glutamatergic insults, which are thought to lead to cell death, neuropil reshaping, and subsequent abnormalities in brain volume. It has been reported that Bcl-2 expression could be an important factor promoting neuronal survival after increased exposure to Glu. An increase in Bcl-2 expression has been also reported to protect cells against the deleterious effect of Glu toxicity
Evidences have shown that Bcl-2 protects neural cells from glutamatergic insults, which are thought to lead to cell death, neuropil reshaping, and subsequent abnormalities in brain volume. It has been reported that Bcl-2 expression could be an important factor promoting neuronal survival after increased exposure to Glu. An increase in Bcl-2 expression has been also reported to protect cells against the deleterious effect of Glu toxicity