THE ROLE OF PROTEIN MISFOLDING AND AGGREGATION IN BSE When a protein misfolds it changes its behavior and function. If it becomes hydrophobic after once being polar. The properties and functionality of the protein are no longer useful to the organism and disaster results. PrPSc is hydrophobic‚ it avoids water inside of the cell…it attracts and attaches other proteins to misfolds and become hydrophobic …Misfolding spreads because the PrPSc act as chaperone proteins to convert PrPc TO PrPSc and
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Design your own experiment: Effect of pH on enzymatic activity Background Information: Trypsin is a protease which conducts hydrolysis forming peptides. It is an enzyme which is secreted by the pancreas into the small intestine and works best in an alkaline environment. Egg white is used in this practical as it is found to contain the protein/ enzyme trypsin. pH is the measure of the amount of H+ ions in a solution‚ these ions affect the shape of the enzyme. Hypothesis: That as pH increases
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Pharmacokinetics The pKa of Bupivacaine is 8.1. It possesses a great degree of lipid solubility and is highly protein bound. It is 14 times more potent than lignocaine. Absorption and distribution The site of injection‚ dose administered‚ addition of vasoconstrictor agent and volume of drug influences the systemic absorption of local anaesthetic. A local anaesthetic solution distributed to an area of greater vascularity leads to greater rate and degree of absorption. The final plasma concentration
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You correctly answered: d. titin 3. In skeletal muscle‚ active force stimulated through a range of muscle lengths Your answer: c. will always be the dominant value contributing to the total force of the muscle. Correct answer: b. will utilize ATP hydrolysis to drive the cross bridge cycle. 4. Which if the following is not depicted in a typical skeletal muscle isometric length-tension curve? You correctly answered: a. time 5. Maximal active tension will be produced in a skeletal muscle fiber when Your
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in this important step. Water‚ acting as the Lewis base‚ removes a proton from the carbon bonded to the nitro group‚ an aromatic benzyl structure is created again: nitroacetanilide; thus ending the nitration reaction (1). Next‚ an acid-catalyzed hydrolysis reaction occurs to remove the acyl group. The nitroacetanilide receives a proton from the sulfuric acid and the double bonded oxygen becomes positively charged. A sp3 hybridized carbon compound is formed once the water attacks the carbon bearing
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Experiment 6: Synthesis of an Alkyl Halide Maria Alexandria Buraga Ammuyutan Institute of Chemistry‚ University of the Philippines‚ Diliman‚ Quezon City 1101 Philippines ------------------------------------------------- Department of Food and Science Nutrition‚ College of Home Economics‚ Univeristy of the Philippines‚ Diliman‚ Quezon City 1101 Philippines ------------------------------------------------- ABSTRACT ------------------------------------------------- Alcohols react with hydrogen
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Introduction: Dependence of Methane Production on Ambient Temperature in Bovine Waste The purpose of this experiment was to determine the effect of temperature in bovine waste on the amount of methane evolved. The hypothesis stated that the bovine waste heated to 48.9oC would produce the most methane. The manipulated variable in the experiment was the temperature of bovine waste. The responding variable was the amount of methane evolved from the waste. The experiment can be applied to real world
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Biochemistry of Muscle Contraction Fred P. Guillergan M.D.‚ FPCP Outline histology and biochemistry of muscles (Striated & smooth) – Myosin – Actin‚ Tropomyosin‚ Troponin – Accessory proteins of muscles Biochemical events in muscle contraction Calcium‚ Ca2+-binding proteins and Ca2+ channels in muscle contraction Biochemistry of Cardiac & Smooth muscle contraction Energetics of muscle contraction ☻Able to understand the normal anatomy and physiology of different types of muscles
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www.igcse.at.ua ORGANIC CHEMISTRY OIL and its many useful PRODUCTS The origin of oil Crude oil is formed from organic material of the remains of plant and animal organisms that lived millions of years ago. These remains form sediments eg at the bottom of seas‚ and become buried under layers of sedimentary rock. They decay‚ without air (oxygen)‚ under the action of heat and pressure to form crude oil over millions of years. It is a fossil fuel because it is formed from
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is replaced with an alkyl group‚ it becomes an ester group. “The reaction typically gives 60-70% of the maximum yield” (Staudt‚ 80). The reaction of an ester could also be reversible to make carboxylic acid and alcohol; this process is called hydrolysis. But when‚ “the base-promoted decomposition of esters yield an alcohol and a salt of the carboxylic acids; this process is called saponification”; In other words‚ it is the process of making soap (Staudt 80). Moreover‚ Esters are liquid at room
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