Chelsea Price Lab Partner: Joey Simmons Abstract: In this experiment‚ benzoin was synthesized from benzaldehyde‚ using thiamine hydrochloric acid as a catalyst. The thiamine HCl was deprotonated by sodium hydroxide and acted as a nucleophile to attack the benzaldehyde. A water-cooled condenser was used to heat the solution at reflux. Vacuum filtration was used to wash and dry the product. The benzoin product was recrystallized by dissolving with a H2O/95% ethanol (2:1‚ v/v) solution
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product and which layer holds the product in each experimental step performed. [pic] Introduction This experiment utilizes SN2 chemistry to convert 1-butanol (n-butanol) to 1-bromobutane (n-bromobutane). The nucleophile for the reaction is Br- ions. The nucleophile in this lab is generated from an aqueous solution of sodium bromide. The sulfuric acid acts as a catalyst in converting
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D. REACTIONS OF ALDEHYDES AND KETONES WITH SODIUM HYDROXIDE (By: Mary Deo Luigi J. Mabunay 1N-3) Objective: To determine the reactions of Aldehydes and Ketones when combined with Sodium Hydroxide. Process: * Obtain 5 clean and dry test tubes * Put 2mL of 40% NaOH solution to test tubes 1‚ 2 and 3 and on test tubes 4 and 5‚ put 10% NaOH solution * Add 10 drops of the following solution: * Tube 1: formaldehyde * Tube 2: benzaldehyde * Tube 3: acetaldehyde
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Experiment 7 General Safety Considerations 1. 1-Butanol and 1-bromobutane are toxic and irritating. Avoid all contact by constantly wearing goggles‚ gloves and working in the hood. Neither of these compounds can be poured down the drain. Like all products‚ 1-bromobutane should be turned in to your TA in a labeled vial. Any excess butanol should be discarded in non-halogenated waste. 2. H2SO4 is extremely corrosive. In very diluted form it can be poured down the drain‚ all other precautions
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by : Directorate of Education‚ Delhi SOME IMPORTANT REASONING BASED QUESTIONS OF ORGANIC CHEMISTRY 1. Chlorobenzene is less reactive than chloromethane. Ans. In chlorobenzene‚ each carbon atom of benzenering is sp2 hyridised and is electron withdrawing. Chlorine atom donates a lone pair of electron and acquire positive charge. The negative charge is delocalised on ortho and para position by resonance. C-Cl bond acquires partial double bond character and is 169 pm as compared to 17.0 pm in chloromethane
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William son Eth er Synth esis Introduction In this reaction‚ an alcohol is deprotonated to form a good nucleophile‚ which then attacks the electrophile methyl iodide to form an ether. Tetrabutylammonium bromide‚ a phase transfer catalyst‚ is used to carry ions back and forth between the organic phase and the aqueous phase. OH O NaOH + NaI + H2O CH3I Before coming to lab‚ please review the following techniques: "Reluxing a reaction‚" "Extraction and washing‚" "Drying an Organic Solvent‚" "Evaporating
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synthesis through the oxidation of benzoin. In order to produce the desired o-diketone‚ the alcohol on benzoin must be oxidized. Nitric acid was the oxidizing agent used in this experiment. As a result‚ the alcohol group on benzoin acted as the nucleophile and attacked the electrophilic nitrogen of nitric acid. As this step forms oxonium‚ excess water in the system deprotonated the oxonium to restore the neutral charge on oxygen. However‚ the organic nitrate was unstable due to its positively charged
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Title: Nitration of Methyl Benzoate Objective: To prepare methyl-3-nitrobenzene from nitration of methyl benzoate. Results and calculations: Density = 1.094 g/ml = Mass of methyl benzoate = 1.094 g/ml x 2.8 ml = 3.0632 g no. of mol of methyl benzoate = = 0.022499 mol 1 mol of methyl benzoate produced 1 mol of methyl m-nitrobenzene. Therefore‚ 0.022499 mol of methyl benzoate produced 0.022499 mol of methl
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little of the enol (ppm or less). However‚ any enol that formed quickly reacted with the strong base to form the enolate ion. Therefore‚ the generation of the enolate drove this reaction to completion (Le Chatelier’s principle). Being a very strong nucleophile‚ this enolate attacked the carbonyl of benzaldehyde and formed an alkoxide ion. This alkoxide ion abstracted a proton from water to form a beta keto alcohol which then tautermerizes to an enol. This enol reacted with base to form yet another enolate
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This lab will allows the comparison between elimination reactions under acidic and basic conditions through an analysis of two separate reactions: an acid-catalyzed dehydration of 1-butanol and 2-butanol using sulfuric acid and a dehydrobromination under basic conditions using potassium tert-butoxide of 1-bromobutane and 2-bromobutane. The products of all four reactions will be analyzed with gas chromatography‚ which separates organic compounds to see how each reaction’s product are formed under
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